Friday, 03 February 2012 15:48

Mechanisms of Therapeutic Action of ADRCs

In the Wall Street press one always reads, when the theme "stem cells" comes up, what the difference in adult- and embryonic cell differentiation potential is and what these magic things all can do, or what they cant do. Words like pluripotency, multipotency and sometimes even the word progenitor cell come up and are the buzz words, in providing an explanation of whats good or bad- which stock you should buy or which one should not touch.

This is very misleading and a lot of rubbish,...

since that is not where the power of most of the emerging technologies lie. Its much more the versatility of injected cells into the body to accomplish certain therapeutic action in different ways- especially in concert with resident endogeneous cells i.e. cells already resident in your body, which serve as receptors or cooperators of the inputted cells . Eric Duckers, investigator and cardiologist from Erasmus, adapted and changed the Cytori slide on "Mechanisms of Action" somewhat to give his view of the most important aspects of therapeutic action, which underscores the power of the Cytori approach (autologous) versus others.

Although it should be understood that different applications have different "main mechanisms"- compare ischemic versus bone growth for instance- the key of the therapeutic action of adult cells relate to cell signaling in different fashions as depicted by the slide below:

The mechanisms of therapeutic action

 

His view on the power of ADRC´s is obviously the acute cardiac case, which however is an important one, since this will determine Cytori´s intermediate

mechanisms

 future to a large degree. That the paracrine action (secretion of cytokines to stimulate local cells to do certain things) is highly relevant in virtually every application is well-known (except by Wallstreet that is)- that homing or trans-differentiation occurs, has long been disputed and has not been proven very often. In my mind, its unlikely, that this occurs extensively in the "first waves" of ADRC applications and that its absence remains that way in the immediate future. At present only about 2% of all inputted cells transdifferenciate or "home" into receptor tissue. This applies probably to all ischemic apps, but will most likely be improved through some manipulation of the cells in the future before being inputted into the patient.

This cell signaling versatility implies the possibility, yes likelyhood, of a very broad- and extensive future application platform and the advantages of a first mover. We will see what Cytori makes of it- the chances for something BIG, are tremendous.

I must admit I have spent very little time on following and trying to understand the technology surrounding embryonic stem cells- yes- I am aware one can remove the nucleus from a spender cell, include a donor cell to obtain a enucleated oocyte and via the blastocyst stage arrive at "customized" stem cells capable of many things. The immunologic- and "directive" issues remain, which I do not believe will be solved anytime soon. Soon I define here as- anytime within 15 years- if at all.

Allogenic stem cell technology to me is purely commercially driven to get an off-the-shelf product and simply gives up on one of the main-FUTURE- reasons for stem cell technology, i.e (trans-) differentiation in view of DNA issues.Thereto carries a substancial amount of immunologic risk

So contrary to what Wall Street is babbling in concert with scientists craving for research grants-I strongly feel that a paradigm change will occur in the next few years and will be based on adult stem cell- and regenerative technology and this science will focus on :

UNLOCKING THE REGENERATIVE POTENTIAL OF CELLS AVAILABLE IN OUR OWN- STRESS-OWN BODY, BY FREEING UP THE RIGHT MIX OF CELLS FROM TISSUES IN WHICH THEY ARE PRESENTLY EMBEDDED AND CAPTURED, SO THEY CAN UNLEASH THEIR TREMENDOUS POWER OF REGENERATION IN AREAS OF NEED IN OUR BODY, WHERE IMBALANCES- OR NECROSIS OF THE HUMAN CELL-AND TISSUE STRUCTURE HAS OCCURRED.

 To conclude just a small explanation of cell signaling as appeared on the sister page -cell-treatment.net in the ASC "explanation" section-

 

 

Extracellular signaling generally means that most signals produced by cells within the body (or introduced into it)bind to receptors that are SPECIFIC for that signal. extra-cellular-signallingMost of these receptors are found on the cell surface of the endogeneous (i.e.resident cells).

Binding of the signal -(also called ligand) to the receptor results in a series of events (signal transduction) within the cell that changes the cells function and the tissue in which it is embedded in a positive fashion. These are all very important processes which explain the magic of adult cell therapy, which are BIOLOGICAL of nature, and which cannot be substituted by pharmaceutical compounds and its side-effects, due to its complexity.

Last modified on Monday, 22 February 2016 05:06

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