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Adult Stem Cell News and Developments other than Cytori
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TOPIC: Man cures Mice

Man cures Mice 14 Feb 2013 10:54 #148

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www.eurekalert.org/pub_releases/2013-02/ctco-scs021313.php

Great news for sick mice. Human adipose stem cells are proven to be the ideal source for treating heart disease in mice. Animal rights activists campaigning for better rodent health care have declared that they want to see trials from younger ADRC doners to see if they are better than that of older human donors. Said one noted FDA official, "its about time we humans gave back to rodents the benefits of research"

Actually, joking aside it would be quite interesting to see if there is a "material" difference between old sick people's ADRC and that of healthy young persons. Shouldn't be too expensive.

One small nail in the bone marrow coffin. Go Fat.
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Man cures Mice 15 Feb 2013 17:11 #154

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Human sourced cells in a rat model- I have read many instances of this occurring, but doubt the value of any conclusions from the study. We all know the angionesis part is most relevant in an autologous human model? :whistle:

Anyway- to stay in Scandinavia for this one- just before my server blew up, I found this paper from Denmark.

Rigshospitalet in Kopenhagen is the clinic where one of the PRECISE patients were treated. Do any of you remember DKK our Danish Dynamite Yahoo poster from 2010 or so? He actually sent me a video broadcast on Danish television o presenting Celution at the clinic.

The Danish doctors did not wait very long and started doing their own thing apparently- with cultured ADRCs.

I have not read it thoroughly- been busy with multi-language website stuff- but the paper appears to be interesting.

Let me know what you think.


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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Man cures Mice 20 Feb 2013 19:00 #177

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Interesting article. Researchers always seem to want to break new ground. In this case they recognise the positive attributes of ADRC, especially the ability to easily retrieve a large volume of cells. They choose to expand them and at the same time culture the cells for 7 days
in VEGF-A165-stimulation medium . They hope that it stimulates vasculogenesis and angiogenesis, ie. to supercharge the ADRC.

The procedure, even starting with high concentration ADRC requires considerable time and effort to create the requisite number of autologous cells. This expansion process is both costly and time consuming and being complex in nature more likely to be prone to error. The interesting thing is they choose to utilise a large number of cells even though it appears that there may be a threshold above which a larger number of cells may not be positive, possibly even negative. If they truly are supercharged there may well be a case for fewer cells being necessary.

The Danish researchers are going forward on a tangent without the research establisment having determined a standard of care utilising regenerative cells. This is the risk that CYTX faces, ie, the increasing knowledge that is growing geometrically from trials being undertaken by researchers all over the world. Having said that, the CYTX model appears to me to be the most cost effective approach of any I have read about so far. The marginal cost of the product apart from the liposuction procedure must be quite small. This provides a huge benefit to CYTX but it should not be squandered through needless delays.

One could make the case that even if the Danish researchers approach is optimal they would probably be well advised to use the Celution equipment to source their original ADRC. If the activation of ADRC with pro-angiogenic factors causes this procedure to be considered as a drug then this may require quite extensive testing before it can be sold in the USA. Hopefully CYTX will have established itself in the meantime as the standard of care.

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