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Cytori´s Technology- Celution, IP etc etc
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TOPIC: Visions of a Clearer Future

Visions of a Clearer Future 13 Oct 2015 06:53 #5296

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On October 12 2015- i.e. yesterday- Okyanos posted the story of Dr. Caren on its website, who was treated a small YEAR ago against wet Macular Degeneration, a devastating eye disease which is also tackled by other cell types.

The intravenous i.e SYSTEMIC treatment has apparently been HIGHLY successful- which should give all shareholders ANOTHER piece of evidence, that the future of cell technology- specifically ADRC technology is bright and the cells simply work...




Read the MAGIC story on the Okyanos site... link : HERE

The end of the story is very important... :winky:

Visions of a Clearer Future
Today Caren and her family celebrate the adventurous decision to try cell therapy. Now about 11 months post-treatment and seeing today in a much brighter light, she says, “I’m doing fabulous!”
After leaving Okyanos, Caren says the medical team prepped her on a reasonable timeline of when she might expect to see sustained improvements. “They had told me I might start to notice positive changes within 9 to 12 months—if it was going to work, it would be somewhere within that time,” she says. But one month after she returned home from Okyanos in The Bahamas, Caren’s eye specialist was surprised to see how well Caren was doing. She had only a very little bit of fluid in her eye and didn’t need an Avastin injection.

Her progress continued with some ups and downs, which were to be expected. “A few months later I did have a little fluid—no blood—and some slight distortion, so I had an [Avastin] injection.” She continued regular checkups, monitoring her progress—each visit showing gradual improvements compared to how things were before cell therapy. However, at a checkup about 8 months post-cell therapy is when she and her doctor were overwhelmed at the results.

“I went for my regular 6-week checkup and after my exam, I as told my eye was completely clear. I had no blood, I had no fluid—nothing in my scans or visually. It was very exciting, after 3 years, to be completely fluid-free in my eye. My doctor was very surprised. He couldn’t account for it, he was stunned! I was very happy, my family was very happy. We all celebrated—it was a big win for us.”
A Little Hope Goes a Long Way
Though Dr. Caren admits she had high hopes for cell therapy, the good news of her improvements was still a very welcome surprise.
“I’ve always had the hope that this would be the answer, because it made sense to me,” she says of the the treatment. “There was a possibility there that I was going to go blind, and that’s very scary. So when somebody does finally tell you, ‘You’re clear, your eye looks great,’ you don’t expect to hear that! It was very overwhelming in a great way.”

Dr Caren - Stem Cell Treatment Wet Macular Degeneration Apart from the improvement in her eye condition, Dr. Caren says she feels an overall sense of better health as a result of cell therapy, and can’t recommend this treatment enough to patients who, like her, live with macular degeneration or other degenerative medical conditions.

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Visions of a Clearer Future 13 Oct 2015 08:31 #5298

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Both fascinating and kind of freaky. Shoot some SVF into the vein and see it go wherever it has to in order for it to heal. A very hard concept for the FDA to confront given that they deal with synthesized drugs to deal with specific illnesses with a known method of action (ideally). This concept of inject it and it will work is alien, super freaky witchcraft for the FDA.

But if you think about it our bodies dispatch healing agents to the site of injury all the time. :grin: ....... and what is SVF, condensed autologous healing agents. :winky:

In the past I recall reading about a doctor (vet) injecting stem cells that they had somehow tagged with a radiocative? dye and after injecting into the animal they did a comprehensive MRI/CAT scan and showed how the SVF cells honed in to a variety sites within the animals body that were injured

It would be most interesting to see something along these lines being undertaken by Cytori. Like they say a picture is worth a thousand words. :yep:

Sometimes what you expect to work doesn't or is delayed as in the case of the ATHENA trials. However in developing the technology for ATHENA we created INTRAVASE which may now have applications in a myriad of other indications. :vegas:

ir.cytori.com/investor-relations/News/news-details/2013/Intravase-Approval-Opens-Vascular-Market-for-Cytori/default.aspx

I would assume that CYTX is kept abreast of the treatment protocols created by OKYANOS. It would be most interesting to see if our patents cover these sorts of indications.(macular degeneration). The potential is huge. If SVF where to become a broadly used low cost treatment for so many indications then the ramifications for the drug industry would be HUGE :bash: :bang:

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Visions of a Clearer Future 15 Oct 2015 08:07 #5300

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I would assume that CYTX is kept abreast of the treatment protocols created by OKYANOS. It would be most interesting to see if our patents cover these sorts of indications.(macular degeneration). The potential is huge. If SVF where to become a broadly used low cost treatment for so many indications then the ramifications for the drug industry would be HUGE


then the ramifications for the drug industry would be HUGE that is the disruptive part and the chance to become a real BIG company, but on the other hand also the "scary" part and the reason why we are where we are. Surely Calhoun could not handle this and made big mistakes. We shall see how we fare from here :whistle:

I would assume that CYTX is kept abreast of the treatment protocols created by OKYANOS.


Guys like Brian Gagnon and Matt were very much in touch with Dr. Mitsuo in Japan, who treated all kinds of patients with UNMET needs- i.e. presently incurable disorders, but MOST were done with Hedrick present according to my sources. So- they should know.

I am certain Matt does well there too and making protocolls for all kind of different disorders and having them blessed by the Bahama government. :yep:

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Visions of a Clearer Future 15 Oct 2015 08:57 #5301

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Fas
Any idea on how the cardiac program is doing in terms of patient recruitment at Okyanos ?

In terms of the systemic route, you may not remember but years ago we had a conversation on the YMB about one knows a strong enough (therapeutic) dose gets to the desired treatment site vs healing other injuries. Do you think we now can harvest sufficient numbers of cells that this isn't such a issue or is the best option to have a intravenous site close enough to the desired location that the bulk of the cells pass this area first.?

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Visions of a Clearer Future 15 Oct 2015 13:36 #5302

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Fas
Any idea on how the cardiac program is doing in terms of patient recruitment at Okyanos ?


To be honest hedge, I am at present (and the past few weeks) only focussed on the natural health of my family and myself. Thats all very challenging and rewarding- since making great progress- but have hardly any other spare time left. And that applies to a pensioner. :grin:
Anyway- surely I will catch up sometime with him.

In terms of the systemic route, you may not remember but years ago we had a conversation on the YMB about one knows a strong enough (therapeutic) dose gets to the desired treatment site vs healing other injuries. Do you think we now can harvest sufficient numbers of cells that this isn't such a issue or is the best option to have a intravenous site close enough to the desired location that the bulk of the cells pass this area first.?


I will never forget Leeza´s story with the broken leg of the mouse... :yep: and ensuing discussions. Generally, yes, from what I have heard of CTX-2 (I have heard from somebody it looks totally different than the little image on the banner on my page here) has sufficient capacity for all therapeutic apps including IV apps especially considering the progress on the liposuction front.

That should apply to all patients with single defined disorders- patients with multi-organ disorders, including metabolic syndrome disorders, surely will require multiple treatments with Celution, due to the multitude of medical insults in the body which all attract the cells... :whistle:

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Visions of a Clearer Future 15 Oct 2015 13:52 #5303

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Yes Yes stay healthy Fas !!!!! :cool: :grin:
Family too !

Since you mentioned Leeza I saw her husband will be presenting at ifats in November. Its been awhile since we have heard from her. I wonder if see will pop in and give us a update ?

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Visions of a Clearer Future 15 Oct 2015 19:09 #5304

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Talking about a clearer future for CYTX, one might want to look at the September slides posted at the CYTX website.

1. One would come to the conclusion that for all the active clinical trials leading to US regulatory approvals have very long way to go (the earliest date is 2018). Even after successful FDA approvals, sales and marketing successes are still uncertain.

Of course, these clinical trials are keeping the company seemly alive in the US, while at the same time, the company would still need a lot more money to keep it alive.

2. Yet, adipose derived cell therapy using the celution system has been shown "somewhat" effective in various clinical applications outside of the US. CYTX's cell therapy appears to have given various regulatory approvals in some EU countries, as well as China, Singapore, Australia, etc. Yet sale and marketing outside of the US appears to be zero.

Some thing is wrong here. If all past r/d efforts yield no income, then what is the point in doing any clinical trial in the US now. Are we barking the wrong tree by not pushing sales more aggressively overseas ? CYTX needs sales/revenue instead of raising cash by borrowing and selling shares at gutter prices.

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Visions of a Clearer Future 15 Oct 2015 21:45 #5305

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Franshei you are correct that 2018 is the expected magic year and a long way off when one is in need of constant cash and even then I haven't changed my much lower 2020 earnings expectations yet until we see what Cytori really gets for scleroderma reimbursement and what the market adoption really is for that and other indications.
I would also agree with your "somewhat" effective statement because I believe some data has been better than other. At least the data we have been allowed to see.
I do disagree on the increased push for sales....we are in survival mode and inefficient sales and marketing strategies seeking a few dollars while still awaiting reimbursements has already been proven to be a fool hardy adventure. The current self pay market along with the general publics knowledge base has also been proven to be limited at this point in time. Especially as we are also still navigating government bureaucracies.

Hopefully in November we can get some sense as to the scleroderma trial recruitment.

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