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TOPIC: University of Pennsylvania Study

University of Pennsylvania Study 19 Feb 2017 10:31 #8884

  • DOV
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Stem cells collected from fat more stable than
previously thought, Penn study shows
Adult stem cells collected directly from human fat are more stable than other
cells such
as fibroblasts from the skin and
have the potential for use in antiaging
treatments, according to researchers from the Perelman School of
Medicine at the University of Pennsylvania. They made the discovery after
developing a new model to study chronological aging of these cells. They
published their findings this month in the journal Stem Cells.
Chronological aging shows the natural life cycle of the cells as
opposed to
cells that have been unnaturally replicated multiple times or otherwise
manipulated in a lab. In order to preserve the cells in their natural state, Penn
researchers developed a system to collect and store them without manipulating
them, making them available for this study. They found stem cells collected
directly from human fat called
adiposederived
stem cells (ASCs) can
make
more proteins than originally thought. This gives them the ability to replicate
and maintain their stability, a finding that held true in cells collected from
patients of all ages.
"Our study shows these cells are very robust, even when they are collected
from older patients," said Ivona Percec, MD, director of Basic Science Research
in the Center for Human Appearance and the study's lead author. "It also
shows these cells can be potentially used safely in the future, because they
require minimal manipulation and maintenance."
Stem cells are currently used in a variety of antiaging
treatments and are
commonly collected from a variety of tissues. But Percec's team specifically
found ASCs to be more stable than other cells, a finding that can potentially
open the door to new therapies for the prevention and treatment of agingrelated
diseases.
"Unlike other adult human stem cells, the rate at which these ASCs multiply
stays consistent with age," Percec said. "That means these cells could be far
more stable and helpful as we continue to study natural aging."
ASCs are not currently approved for direct use by the Food and Drug
February 17, 2017 at 6:35 PM
Stem cells collected from fat more stable than previously thought, Penn study shows
Saved from URL: www.news-medical.net/news/20170217/Stem-cells-collected-from-fatc2a0are-more-stable-than-previouslythought-
Penn-study-shows.aspx
P
/2 1
ASCs are not currently approved for direct use by the Food and Drug
Administration, so more research is needed. Percec said the next step for her
team is to study how chromatin is regulated in ASCs. Essentially, they want to
know how tightly the DNA is wound around proteins inside these cells and how
this affects aging. The more open the chromatin is, the more the traits affected
by the genes inside will be expressed. Percec said she hopes to find out how
ASCs can maintain an open profile with aging.
Source:
www.pennmedicine.org/news/newsreleases/
2017/february/stemcellscollectedfromfatmayhaveuseinantiagingtreatments
Stem cells collected from fat more stable than previously thought, Penn study shows
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University of Pennsylvania Study 19 Feb 2017 13:21 #8885

  • rodney.strongg
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DOV, an interesting Study - thanks.

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