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TOPIC: PubMed study using Celution

PubMed study using Celution 23 Mar 2015 13:17 #3926

  • mikeadd@twitter
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This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message
Sender's message: adrc treatment
Sent on: Mon Mar 23 12:29:59 2015
1 selected item: 25710946

PubMed Results
Item 1 of 1 (Display the citation in PubMed)

1. Surg Innov. 2015 Feb 20. pii: 1553350615572656. [Epub ahead of print]
Adipose Tissue-Derived Regenerative Cell-Enhanced Lipofilling for Treatment of Cryptoglandular Fistulae-in-Ano: The ALFA Technique.
Borowski DW1, Gill TS2, Agarwal AK2, Tabaqchali MA2, Garg DK2, Bhaskar P2.
Author information:
• 1North Tees and Hartlepool NHS Foundation Trust, University Hospital of North Tees, Stockton-on-Tees, UK This email address is being protected from spambots. You need JavaScript enabled to view it..
• 2North Tees and Hartlepool NHS Foundation Trust, University Hospital of North Tees, Stockton-on-Tees, UK.
Abstract
Background. The treatment of complex fistulae-in-ano is challenging and often includes a number of operations due to high rates of recurrence. Recently, techniques using in vitro expanded adipose tissue-derived stem cells have been described. We describe a novel treatment for cryptoglandular fistulae used in 7 patients, using a combination of surgical closure of the internal opening and real-time autologous adipose tissue-derived regenerative cells (ADRC)-enhanced lipofilling, without need for in vitro expansion. Methods. Following exclusion of active perianal sepsis, patients underwent a standard tumescent liposuction procedure, harvesting ~300 to 400 mL of raw lipoaspirate. The lipoaspirate was prepared in real time, using the Celution 800/CRS system to obtain the stromal vascular fraction containing ADRCs. After excision of the fistula tract and closure of the internal orifice, fresh ADRC-enhanced lipoaspirate was injected into and around the fistula tract. Results. At 6-months' follow-up, 5 of 7 (71.4%) patients showed clinical signs of fistula closure; one of these patients had a recurrence at 10 months due to sepsis. The remaining 4 patients (57.1%) all had complete fistula closure at a median of 46 months' follow-up. There were no adverse events associated with the technique, and no new incontinence. Conclusion. Treatment of cryptoglandular fistulae-in-ano with ADRC-enhanced lipofilling appears feasible and safe, and may add to the range of procedures that can be used to treat this difficult problem.
© The Author(s) 2015.
PMID: 25710946 [PubMed - as supplied by publisher]
The following user(s) said Thank You: fas, d9dozrman, fatboy, LTCytx

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PubMed study using Celution 23 Mar 2015 13:29 #3927

  • fas
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Thanks Mike- I see you managed to post afterall. Well done.

Just as a reminder to everyone- in 2012 Cytori ALSO received specific device approval on Cryptoglandular fistulae treatment, after the infamous fistulae after Crohn´s approval was received in 2010. All in the EU of course.

Cytori also reported (back in 2013 I believe) that a private investigator sponsored trial was commenced in Japan for this indication (Cryptoglandular). This app should have a chance to receive conditional approval in Japan. :whistle:

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:
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