Half a can of coke of fat tissue extracted from the subcuteneous part of the belly, is the standard introduction by all presenters of Cytori managers at Investor conferences over the past eight years, when they start describing what amount of fat is needed from a patient before that fat is processed by Celution to extract a therapeutic dose of regenerative cells for a medical application.
I still do not know what size can of coke is actually referred to, but it has been stated at various occasions, that even with skinny persons it is no problem at all to harvest 250 to 300 cc of fat from the subcutaneous part of the belly. More is generally assumed to be no issue at all too.
In light of the recent decision by Cytori to have ATHENA II following the completion of the cardiac ischemia clinic ATHENA with a higher dose of ADRCs (most likely influenced by outside sources either FDA or potential partner) , it is certainly interesting to have a closer look at the issues surrounding the extraction of ADRCs with Celution and determine what is possible and what might provide issues. Clear is that Cytori in the past ALWAYS has preached that 20-30 Mio viable cells was most likely the optimal dose for the cardiac application, due to limited availability of endogeneous receptor cells, which are assumed to have by means of cell-to-cell interaction, its most effective therapeutic mechanism of action.